About Fillers Restylane family of fillers ( Restylane, Restylane Lyft, Restylane Silk, Restylane Refyne, and Restylane Defyne), filler treatments, also known as injectable cosmetic dermal fillers. Dermal fillers do not affect muscle activity. Instead, these injectable products enhance appearance by adding volume. Volume loss occurs in the aging face. Volume loss can be as responsible for an aged appearance as skin laxity. In fact, soft tissue volume loss contributes to skin laxity. Rather than routinely tightening loose and wrinkled skin,